I put this together when I was trying to keep four computers up to date during the whole 0.9.0 - 0.9.3 mess. It's a summary of how I take a fresh install of Firefox and set it up just the way I like it.

Installation:

Download Firefox

Extensions:

Modifications:

Customize menu bars: get rid of search bar, "Go" button. Small icons, relocate bookmarks/url bar. Disable bookmarks toolbar.
Bookmarks
In about:config
     image.animation_mode - set to none
     browser.blink_allowed - set to false
     dom.disable_window_open_feature.resizable - set to true
     accessibility.typeaheadfind.enablesound - set to false
     browser.enable_automatic_image_resizing - set to false

Tools/Options:
     Privacy: disable form information, etc; cookies for current session only
     Content: disable java and javascript junk
     Tabs: single window mode, don't hide tab bar
     Downloads: ask for all downloads, don't show DL manager
     Advanced: don't resize images, use smooth scrolling
Add to usercontent.css:
marquee { 
   -moz-binding                  : none !important; 
   display                       : block; 
   height                        : auto !important; 
}
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